Medicament and diluent storing, mixing, and dispensing device



Dec. 25, 1962 5. J. SARNOFF ETAL MEDICAMENT AND DILUENT STORING, MIXING,AND DISPENSING DEVICE Filed Feb. 25, 1959 3 Sheets-Sheet 1 ATTORNEY m WWW a 9 7 9 5 4 6 {Q g g 3 Q fl///// .6 7 A/ g a ,0 i m a g 5 w a 5 5 1 E32 a.

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S. J. SARNOFF ETAL MEDICAMENT AND DILUENT STORING. MIXING, ANDDISPENSING DEVICE Dec. 25, 1962 Filed Feb. 25, 1959 job United StatesPatent 01 3,070,093 MEDICAMENT AND DILUENT STORING, MlXING, ANDDISPENSHNG DEVICE Stanley J. Sarnoff and George B. Caikins, both of 7505Hanrden Lane, Bethesda, Md. Filed Feb. 25, 1959, Ser. No. 795,395 7Claims. ((31. 128-472) This invention relates to improvements inmedicament and diluent storing, mixing, and dispensing devices, andparticularly to such devices for storing medicament and diluent inseparate chambers within a composite device provided with means forefiiciently mixing the medicament and diluent and subsequentlydispensing the mixture by either drip or syringe type of action withoutthe need of separate handling of the medicament or diluent and withcomplete safety against contamination or spilling of the medicamentduring the use of the device.

In medical technology it has often been found that vaccines and othermedicaments require special storage facilities, and that in many cases adried vaccine or other medicament has superior preservative qualities tothe same material in its diluted ready-to-use liquid form. It is notunusual, therefore, to make and store vaccine and medicament in dry formand to mix them with a desired diluent shortly before they are used.This mixing of a dry material with a liquid diluent often entails theuse of a plurality of receptacles and, in some instances, a spilling orsplattering of vaccine or medicament occurs and may be harmful to thetechnician preparing the mixture.

It is an object of this invention to provide an improved device forseparately storing and for mixing and dispensing a vaccine or medicamentand a diluent, which will provide for the ready mixing of the twomaterials without the possibility of spilling or leaking of the materialfrom the mixing containers during the mixing operation and with aprovision for the immediate availability of the mixed materials from themixing device for use without the need of transferring the mixture toany other container.

It is another object of this invention to provide an improved device forseparately storing dry vaccine or medicament and a diluent inpredetermined proportions to provide a desired mixture which can bereadily prepared within the device and dispensed directly therefromafter mixture of the materials.

A futher object of this invention is to provide an im proved device forseparately storing and for mixing and dispensing a medicament anddiluent in predetermined proportions.

Further objects and advantages of this invention will become apparentfrom the following description referring to the accompanying drawingsand the features of novelty which characterize this invention will bepointed out with particularity in the claims appended to and forming apart of this specification.

In the drawings:

FIG. 1 is a longitudinal sectional view through an improved deviceincorporating an embodiment of this invention for separately storing andfor mixing and dispensing medicament and diluent in which the medicamentstorage chamber is shown as being of the non-vented type and thedispensing end of the device is of the drip type;

FIG. 2 is a longitudinal sectional view of one end of an impovedmedicament and diluent storing, mixing, and dispensing device which mayembody the general features of FIG. 1, and in which the medicamentstorage chamber and associated end of the diluent chamber are ofmodified construction providing for a venting of the medicament chamberand also constructed as a dual medicament chamber, whereby twomedicaments may be separately stored, if desired;

3,670,093 Patented Dec. 25, 1962 FIG. 3 is a longitudinal enlargedfragmentary view of the cooperating sealing and mixing nozzle ends ofthe medicament and diluent chambers of the device shown in FIG. 2;

FIG. 4 is a longitudinal sectional view of the mixing end of a device,such as that shown in FIGS. 1 and 2, illustrating another arrangement ofthe sealing and mixing nozzle ends of the medicament and diluentchambers of the device wherein the medicament chamber is shown as beingor" the unvented type;

FIG. 5 is a longitudinal sectional view of a device embodying thepresent invention, similar to that shown in FIGS. 1, 2, and 4, providedwith a vented type medicament chamber-and a positive seal of thematerial mixing passageway between the medicament and diluent chamberswhich incorporates a positive securing means, as well as improved lipseals, for assuring against accidental mixture of the materials in themedicament and diluent chambers;

FIG. 6 is a fragmentary enlarged sectional view of the positive securingand sealing arrangement of the device shown in FIG. 5 for sealing thepassageway between the medicament and diluent chambers;

FIG. 7 is a sectional fragmentary view of another embodiment of animproved device incorporating the present invention, wherein asimplified securing and mixing orifice sealing construction isillustrated in connection with a medicament chamber and the associatedend of a diluent chamber;

FIG. 8 is a sectional view, taken along line 8-8 of FIG. 7, illustratingthe relative arrangement and securing lug structure for latching themixing orifice sealing means between the medicament and diluent chambersof this device;

FIG. 9 is a longitudinal sectional view of the mixing end of a deviceincorporating the present invention illustrating another type ofmedicament storage chamber and associated mixing orifice end of adiluent chamber, in which the medicament chamber is shown provided withventing plug means; and

FIG. 10 is a longitudinal sectional view of a device incorporating thepresent invention for separately storing and for mixing and dispensingmedicament and diluent, wherein an imperforate diaphragm separates themedical ment chamber from the diluent chamber for storage purposes, anda fluted sharp piercing element is secured to the medicament chamber toprovide for piercing of the diaphragm and for the passage of diluentthrough the diaphragm into and out of the medicament chamber from thediluent chamber,and in which the opposite end of the device isillustrated as provided with a syringe type nozzle connector.

Referring to the drawings, an embodiment of an improved device forseparately storing and for mixing and dispensing a medicament or vaccineand a diluent is illustrated in FIG. 1, which incorporates thisinvention wherein the device is of a type provided with separatemedicament and diluent storage chambers which are of a mutually sealingtype. In this construction, the diluent chamber comprises a relativelylarge diluent containing shell 1, preferably substantially cylindricaland also preferably formed of a pliable plastic. One end of the shell 1is formed with a mixing nozzle 2 extending over the end of the shell andprovided with a central mixing supply passageway 3. An end 4 of themixing nozzle 2 preferably is generally conical in shape and is providedwith a passageway 5 extending from the outer end of the supplypassageway 3 and terminating in an orifice in the end of the mixingnozzle 2. The outer end of the mixing nozzle 2 is adapted to extend intothe medicament chamber to provide for the ready passage of diluent or amixture of diluent and medicament between the diluent and medicamentchamber.

In order to assure the desired separate storing of medicament anddiluent in a single composite device formed by the diluent andmedicament chambers, the medicament chamber is formed in this embodimentas a mixing head having a medicament chamber wall 6, preferably ofcylindrical form, which is closed at one end by a suitable end wall orcap 7 and terminates in a screw threaded internal shoulder 8. Thisthreaded shoulder 8 on the end of the mixing head is adapted to securethe mixing head to the diluent chamber by screw threaded engagement witha complementary threaded portion 9 of the mixing nozzle 2, and thesethreaded engaging portions of the mixing head and the diluent chambernozzle are of such proportions as to provide for securely drawing up themixing head over the nozzle so as to seal the orifice end of thedispensing passageway in the end of the nozzle. This scaling function ofthe mixing head is obtained by forming a socket lib on the inner side ofthe end wall 7, which is adapted to provide a snug sealing engagementwith an outer sealing surface portion 11 on the end of the dispensingnozzle 4-.

In order further to assure a good seal between the socket 1t) and thesealing surface portion 11 of the nozzle, the shoulder b is adapted tobe screwed over the threaded portion 9 so as securely to press the endof the nozzle 4 into the socket 10. This is readily provided for bydimensioning the threaded shoulder of the mixing head and the threadedportion of the nozzle so that when the mixing head is screwed outwardlyfrom the nozzle to provide for ready passage of diluent from the diluentchamber into the mixing head, the space A between the orifice end of themixing nozzle and the end of the socket in the mixing head end wall 7 isless than the distance B between the edge 8' of the threaded shoulder 8and the adjacent end surface of a shoulder 1 at the end of the threadedportion 9 of the nozzle. In order to provide further for a tight sealingengagement of the end of the nozzle 4 in the socket it) as the mixinghead is screwed down over the nozzle, the inner surface of themedicament chamber wall 6 is formed with a groove 12 extendinglongitudinally of the medicament chamber from the inner end of thethreaded shoulder 8 for a distance A sufficient to allow the threadedportion 8 to be screwed over the threaded portion 9 of the nozzle tobring the orifice end. of the nozzle into tightly pressed engagement inthe socket 10,

The engagement of the threaded shoulder 8 of the mixing chamber with thethreaded portion 9 of the diluent chamber nozzle forms .a seal whichassures against accidental spilling of medicament or diluent from thedevice both during storage and during mixing and dispensing of themedicament and the diluent.

In order further to assure against accidental spilling of material fromthe device, the mixing head preferably is formed with an inwardlyextending shoulder 13 which extends from the end of the groove 12inwardly of the mixin head to the inner end of the medicament chamher,and a pair of sealing O-rings 14 is formed on the outer surface of anunthreaded shoulder 15 on the nozzle 4 adjacent to the threaded portion9 thereof of a size adapted to provide a snug sealing engagement withthe inner surface of the shoulder 13 on the mixing head. These sealingO-riugs preferably are spaced apart so as to provide a leakage materialreceiving groove therebetween, which further assures against the leakageof material out of the device along the relatively movable securing andsealing surfaces thereof.

This type of medicament and diluent storing and mixing device is adaptedto be filled for storage purposes with the'medicament and diluentseparated and sealed from each other in their respective chambers of thedevice. When it is desired to utilize the device, the diluent is mixedwith the medicament and then'is adapted to'be l dispensed by either adrip or syringe dispensing means.

In order to store the medicament and the diluent in their respectivechambers of the device and to provide for the most efficient utilizationof the space within the device, the desired medicament in powder orother suitable form is placed within the cup-shaped medicament chamberformed by the mixing head walls 6 and 7, and the mixing nozzle 2 of thediluent chamber then is screwed into the threaded shoulder 8 of themixing head until the end of the nozzle is pressed into snug sealingengagement with the socket 10 in the mixing head end wall 7. Thisprovides a leak-proof seal of the medicament within the medicamentchamber of the mixing head. The diluent chamber then is completelyfilled with diluent to the inner side 16 of a shoulder 16, and thediluent chamber then is closed by a suitable drip or syringe head. Thishead may be made as the dispenser or may be made as a terminalconnection for a drip or syringe dispenser, and is shown in FIG. 1 as adrip type dispenser head. In such a construction, the dispenser head 17preferably is formed with a sealing flange or shoulder 18 which isadapted to have a snug sealing fit within the inner surface of theshoulder 16' on the end of the diluent chamber wall 1. Such a head 17 ispressed into the end of the diluent chamber flange 16 until the innersurface 17 thereof is substantially flush with the inner side 16 of thediluent chamber shoulder 16, and then preferably is sealed thereto inany suitable manner, as by heat sealing of the engaging surfaces of theshoulders 16' and flange 18. Such a seal can readily be made if thedispensing head 17 is made of suitable plastic material Which can bereadily heat sealed to the plastic material of which the diluent chamberwall 1' also is made. The dispensing head 17 is formed with an axiallyextending dispensing passageway 19 which terminates in a relativelysmall passageway 19 through a drip dispensing nozzle 20, formed on theouter end of the dispensing head, so that material from the device canbe dispensed a drop at a time through the small passageway 39' bysqueezing the pliable plastic wall 1 of the diluent chamber. In thismanner an exact dispensing of the desired quantity of mixed medicamentand diluent can be dispensed as desired.

In order to assure against spillage or leakage of the diluent from thedevice during storage and during mixing of the diluent and medicament, aclosure cap 21 formed of any suitable material, such as plastic, isadapted to be arranged over the dispensing nozzle 26 and to seal thedispensing passageway 19' thereof. This closure cap 21 may convenientlytake the form of a screw cap having internal threads 22 which are formedand adapted to engage complementary screw threads 23 on a shoulder 23formed on the end of the dispenser head 17, such that a socket 24 formedin the end of the closure cap 21 can be drawn into tight sealingengagement over the outer surface of the dispensing head nozzle 20. Inthis manner, the device can be filled with a predetermined amount ofmedicament and diluent, sealed in separate chambers of the device forstorage purposes, with assurance that these materials will not becomemixed or contaminated during storage.

When it is desired to use the medicament, the mixing head is screwedoutwardly from the diluent chamber to a position corresponding to thatshown in FIG. 1, so that the end of thenozzle 4 is free of the sealingsocket it). The device then is held in a position with the mixing headand the nozzle extending downwardly and the sides of the pliable plasticdiluent chamber 1 are alternately squeezed and released so as to causediluent to flow alternately from the diluent chamber into the medicamentchamber and back from the medicament chamber into the diluent chamber.In this manner, the medicament and diluent may be thoroughly mixed,while maintaining'a complete seal of these materials within the device.After the material has beerrthoroughlymixed, the

closure cap 21 can be removed from the dispensing head 17 and the mixedmaterial within the diluent chamber can be dispensed a drop at a timethrough the small passageway 19' in the drip nozzle 20, therebyproviding for a complete separate storage of medicament and diluent, amixing of the medicament and diluent without the transfer of either ofthese materials from any separate container for the mixing operation,and a dispensing of the mixed medicament and diluent from the devicewithout any transfer of the material to any separate dispenser. Thisassures against any possible contamination of the material before itsuse, and also assures against spilling or splattering of the vaccine ormedicament on the personnel preparing or dispensing the material.

In FIGS. 2 and 3, another embodiment of the improved device forseparately storing and for mixing and dispensing medicament and adiluent is illustrated. In this construction, as in that shown in FIG.1, the diluent chamber may be formed of a shell of pliable plastic andmay be provided at one end thereof with a suitable dispensing head ofthe drip or syringe type for dispensing material from the device and forclosing one end of the chamber during storage and mixing operations.

The other end of the diluent chamber is formed with a sealing capportion 26 preferably integral with the shell 25 and provided with amixing nozzle 27 on the outer end thereof. This mixing nozzle 27 isformed with an axially extending central passageway 28 preferably havinga plurality of transversely extending slots or apertures 28 extendingfrom the passageway 28 to the outside of the mixing nozzle 27 to providefor the passage of diluent in and out of the diluent chamber through themixing nozzle 27 and into a suitable medicament chamber.

In certain instances, it may be desirable to store separately twodifferent medicaments and also to store these two medicaments separatelyfrom a common dilueat, all three of which are adapted to be mixed and tobe dispensed as a mixture. The construction shown in FIGS. 2 and 3illustrates a type of medicament chamber which may be utilized for suchplural medicament storage and mixing purposes. In this construction. themedicament chamber may be formed in a mixing head provided with an outermedicament storing chamber 29 and an inner medicament storing chamber 33formed by substantially concentric cylindrical walls 31 and 32,respectively, which extend axially from a common end wall 33 of themixing head.

Separate storage of the medicaments in the chamber 29 and 30, sealedfrom each other and from the diluent, is assured by providing a securescrew threaded engagement between the mixing head and the diluentchamber and providing additional seals between engaging surfaces ofthese two members of the device, similar to those of the FIG. 1construction. These can conveniently be provided by complementary screwthreaded shoulders 34 and 35, respectively, adjacent the ends of themedicament chamber wall 31 and the diluent chamber cap portion 26 whichare adapted to draw these two elements tightly together and to provide aliquid seal through the threaded engagement of these two members. Inorder further to assure against the mixing of the plural medicatmentswith each other, or with the diluent during storage thereof, the capportion 26 of the diluent chamber is provided with an end wall 26'having a groove 36 formed in the outer surface thereof complementary tothe end surface or edge 32 of the central medicament chamber wall 32, sothat when the mixing chamber is tightly screwed onto the cap portion 26,the end surface 32 of the wall 32 is pressed into tight sealingengagement with the surface of the groove 36 and prevents the passage ofmedicament from one medicament chamber into the other and also preventsthe passage of diluent from the diluent chamber into the outermedicament chamber.

The passage of medicament from the inner medicament chamber into andmixture with diluent in the diluent chamber or medicament in the outermedicament chamber also is prevented by sealing of this inner chamber bya special sealing arrangement. This arrangement includes a suitablesealing O-ring 37 formed on the mixing nozzle 27, which is adapted tohave a snug sealing engagement with the inner surface of the cylindricalmedicament chamber Wall 32 when the mixing cap is screwed into storageposition, as shown in FIG. 2. In order further to assure against leakageof material during storage, the outer surface of the end wall 26'preferably also is formed with another sealing 'O-ring 38, which isadapted to engage an adjacent surface of a shoulder 39 formed on theinterior of the mixing head wall 31. As shown in FIG. 2, this sealingO-ring 38 is pressed into tight sealing engagement with the surface ofthe shoulder 39 when the mixing head is drawn tightly into storageposition. Further assurance against leakage both during storage andduring mixing operations is obtained by providing a pair of sealingO-rings 40 on the outer surface of the sealing cap 26, which are adaptedto have a snug sealing fit with the inner surface of a shoulder 41 onthe mixing head wall 31 between the shoulder 39 and the screw threadedshoulder 34.

In order to facilitate mixing of the medicaments and the diluent, itoften is desirable to provide a substantially leak-proof vent for thevarious chambers which will provide an effective seal for storage andwhich can be readily opened when it is desired to mix the medicamentsand the diluent. Such a vent can be provided in any of the devicesincorporating the present invention, and may take a variety of suitableforms. One of these is illustrated in FIG. 2 and includes the provisionof a venting plug 42 having a screw threaded stem 43, which is adaptedto have a fluid-tight threaded engagement with a screw threaded aperture44 formed in the mixing head end Wall 33. A relatively small axiallyextending vent passageway 45 extends into the stem 43 from. the outerend thereof and terminates in a transversely extending small ventpassageway 46. This transverse passageway is spaced axially of the stem43 from the inner surface 47 a distance such that, when the venting plug42 is tightly screwed into the aperture 44, the transverse passage 46will be effectively sealed, thereby preventing the escape of materialthrough the vent passageways 45 and 46. In order to assure a good sealbetween the vent plug and the mixing chamber, a sealing O-ring 48preferably is formed on the outer surface of the mixing head end wall 33adapted to engage the inner surface 47 of the vent plug and to bepressed into sealing engagement therewith when the vent plug is tightlyscrewed into its sealing position in the aperture 44.

This construction assures against leakage of any material out of theinner medicament chamber during storage, and provides for a venting ofthe mixing head by unscrewing the vent cap from the mixing head so thatthe ends of the transverse passageway 46 are exposed to the atmospherewhen it is desired to unscrew the mixing head into mixing position onthe diluent chamber. When a vent plug of this type is provided it isadvisable to hold the device with the mixing head up, that is, above thediluent chamber so as to prevent leaking or dripping of material fromthe device through the vent passageways. Mixture of the materials in thedevice may conveniently be accomplished in the same general manner as inthe embodiment shown in FIG. 1 simply by unscrewing the mixing head ashort distance from its sealed position, as shown in FIG. 3, until themixing nozzle 27 is disengaged from the inner end of the innermedicament chamber wall 32. In this position, the mixing nozzle slots28' are opened into the mixing head and diluent may be forced into themixing head by simply squeezing the pliable plastic sides of the diluentchamber shell 25 to force diluent through the mixing nozzle and into themedicament chambers. In order to assure proper mixture of the diluentwith the medicaments, the diluent chamber should be as full as possibleof diluent, so that it will readily pass from the diluent chamberthrough the mixing nozzle when the sides of the diluent chamber shell 25are squeezed. This is particularly important as if the diluent chamberis not full, it would be necessary to squeeze the walls of the shell 25until all of the air in the diluent chamber had been squeezed out of thechamber before any of the diluent would pass upwardly and out throughthe mixing nozzle slots 23 into the medicament chambers. A simplerepetition of the squeezing and releasing of the pliable sides of theshell 25 will provide for a thorough mixing of the diluent and the twomedicaments in the two medicament chambers and a drawing of this mixtureinto the diluent chamber, from which it can be dispensed by any suitabledrip or syringe dispensing head.

FIG. 4 illustrates another embodiment of the present invendon similar tothat shown in FIGS. l--3, in which a diluent chamber is formed by ashell having a pliable plastic wall 49 and a mixing nozzle t) having anaxially extending mixing passageway 51 formed in an end wall 52. In thisconstruction, the mixing nozzle passageway is adapted to be sealed forstorage purposes by a construction which is essentially the reverse ofthe sealing socket arrangement shown in FIG. 1. In the presentembodiment, the mixing passageway 51 terminates exteriorly in acounter-sunk aperture 53 which forms a socket into which sealing plug 54formed on the inside of an end wall 55 of a mixing head 56 is adapted tobe pressed into sealing engagement. The mixing head 56 is adapted to bedrawn into sealed position over the mixing nozzle 5G by threadedengagement of complementary threaded surfaces 57 and 58 adjacent to theends of the mixing head and mixing nozzle, respectively. In order toassure against leakage or splashing of material during the mixing ofdiluent and medicament, a pair of sealing O-rings 59 are formed on theouter surface of the mixing nozzle and are adapted to have a snugsealing engagement with the inner Side surface of the mixing head 56.

In a construction such as that illustrated in this figure, medicament isadapted to be placed in the ment chamber formed in the mixing head 56,and the diluent chamber then is adapted to be screwed into the mixinghead until the mixing passageway 51 in the mixing nozzle is sealed bythe plug 54. In order to assure a complete sealing of this passageway,the plug 54 preferably is formed with a sealing O-ring 69 on a taperedend surface 54' of the plug, such that when the mixing head i is drawnup tightly on the mixing nozzle, the O-ring 6% is securely pressed intotight sealing engagement with the surface of the counter-sunk aperture53. The procedure for filling the diluent chamber and for mixing diluentand medicament and dispensing the mixture from the device issubstantially the same as that for the embodiment shown inFIG. 1.

Another embodiment of this invention is illustrated FIGS. 5 and 6 inwhich the dispensing end of the device may take any suitable form, suchas that shown in FIG. 1. In this construction, the diluent chamber isprovided with a substantially cylindrical pliable side wall 61,preferably of plastic, which terminates in a sealing and mixing endportion 62. This end portion 62 is adapted to extend within a side wallportion 63 of a mixing head and is provided with a pair of sealingO-rings 64, which are arranged with a snug sealing engagement with thesurface of the mixing-head side wall 63. The mixinghead side wall '63preferably terminates with an inturned flange 65 on the inner endthereof, which is adapted to be pressed over the O-rings 64 and to havea snug sliding engagement with the outer surface of the cylindrical sidewalls 61 of the diluent chamber. This inturned flange 65 and the sealingO-ring 64 form a set of liquid seals whichprevent the passage of liquidalong the adjacent surfaces of the walls 61 and d3 of the diluentchamber and the mixing head, respectively. Furthermore, the inturnedflange provides a stop with the adjacent O- ring as, which prevents thecomplete removal of the mixing head from the diluent chamber unless avery excessive force is applied thereto. This further minimizes thepossibility of spilling or splashing of medicament on users of thedevice.

In this construction, the mixing end portion 62 is formed with an endwall 66 having a central threaded mixing aperture 67 therein. The mixinghead is formed with a mixing aperture sealing plug 63, which extendsinwardly from an end wall 6? and is formed with a threaded end portion7t) adapted threadedly to engage the mixing aperture 67 to secure themixing head to the diluent chamber in aperture sealing relationship. Aspecial sealing arrangement is provided for assuring against the passageof materials between the diluent chamber and the medicament chamberwithin the mixing head. This sealing arrangement includes a sealing lip71 formed on the diluent chamber side of the end wall no of the diluentchamber and extends inwardly of the aperture 67. Another sealing lip 72is formed on the sealing plug 68 and extends outwardly, such that whenthe mixing head is drawn into aperture sealing position by screwing thesealing plug 63 tightly into the threaded aperture 67, the end of theSealing plug portion 7% will engage the sealing lip 71 to form a tightliquid seal therewith and the sealing lip 72 will be drawn into tightsealing engagement with the adjacent surface of the end wall as andprovide another liquid seal therewith.

As in the construction shown in FIG. 2, a suitable vent may be providedbetween the medicanent chamber 73 and atmosphere to facilitate mixing ofmedicament and diluent during the mixing of materials in the device.This may conveniently take the form of a transversely extending ventingpassageway 74 formed in the sealing plug 68 which communicates with anoutwardly extending threaded passageway 75 into which a vent plug 76 issecured. The vent plug 76 n ay take the same general form as that shownin MG. 2, in which a threaded stem 77 is adapted threadedly to engagethe threaded passageway 75 and is formed with a small axially extendingvent passageway 78, which terminates at one end at the end of the ventplug stem 77 and at the other end in a small transversely extending ventpassageway 79 formed in the stem 77 and spaced from the adjacent surface80 of the vent plug. As in the construction shown in FIG. 2, a sealingO-ring 81 preferably is formed on the outer surface of the end wall 69and is adapted to engage the adjac nt surface 8i) of the vent plug toform a seal therewith when the plug is screwed into its vent sealingposition, as shown in FIG. 5. Venting of the device can be obtained bymerely screwing off the vent plug 76 a short distance, so as to breakthe seal of the O-ring 81 with the adjacent surface t} of the vent plugand thereby expose the ends of the transverse vent passageway 79. I

The device is adapted to be assembled with medicament and diluent inpredetermined quantities. This may easily be done by placing the desiredamount of medicament in the medicament chamber 73 and then pressing thediluent chamber into the end of the mixing head and screwing thethreaded end portion 70 of the sealing plug 68 into sealing position inthe threaded aperture 67 of the diluent chamber end wall 66. Apredetermined amount of diluent then is placed within the diluentchamber, preferably filling the chamber, and the dispensing end of thediluent chamber then is closed by a dispensing head in any suitablemanner, as explained with reference to FIG. 1. In this manner, themedicament and the diluent can safely be stored in their respectivechambers until it is desired to use them. A solution of the diluent andmedicament then can readily 'be made by merely unscrewing the sealingplug portion 70 from the threaded aperture 67 and mixing the contents ofthe diluent and medicament chambers, as in the previously describedembodiments of this invention. In a construction such as this, it willbe found desirable to back off the vent plug '76 to provide for aventing of the medicament chamber prior to its being unscrewed from thediluent chamber, so as to avoid the formation of a vacuum in themedicament chamber. If desired, additional sealing of the device forstorage purposes can be obtained by providing another sealing O-ring 82on the end surface of the diluent chamber and forming the side wall 63of the mixing head with an inwardly extending shoulder 63 which isadapted to engage the sealing O-ring 81 when the sealing plug 68 issecurely screwed into sealing position in the threaded aperture 67. Thiswill further assure against leakage of material from the device duringperiods when it is kept in storage.

FIGS. 7 and 8 illustrate another embodiment of this invention in whichseparate diluent and medicament chambers are provided which are securedtogether in relatively movable and substantially leak-proof relationshipto provide the advantages of such construction for separately storingmedicament and diluent, and providing for opening a passage betweenthese chambers by relative movement of the chambers to provide formixing of the medicament and the diluent preparatory to dispensing themixture from the device.

In this construction, as in the formerly described structures, thediluent chamber is provided with a substantially cylindrical pliableside wall 83 formed of suitable material, such as plastic, and isprovided at one end thereof with a suitable closure and dispensing head,which may take the form of either a drip or syringe dispenser. Theopposite end of the diluent chamber is provided with an end wall 84having a plurality of passageways or orifices 85 therethrough, which areadapted to provide communicating passages between the diluent andmedicament chambers. As in the previously described constructions, themedicament chamber is formed by a mixing head having a side wall 86 andan end wall or cap 87, which are adapted to form a substantiallyleak-proof closure around the mixing end of the diluent chamber. Themixing head is secured to the diluent chamber by a simple pressedleak-proof fit. This is provided by forming it with an inwardlyextending annular flange 88 on the end of the wall 86 opposite the endwall 87, and the inner diameter of the annular flange 88 is such thatthe flange forms a snug substantially leak-proof fit with the outersurface of the side wall 83 of the diluent chamber. The mixing head thenis secured in position by simply pressing the inturned flange 88 over anoutwardly tapered locking flange 89 on the mixing end of the diluentchamber.

In order to provide an easily operable sealed mounting of the mixinghead, it is resiliently held in position by a flexible mushroom typeclosure member. This closure me ber includes a flexible closure plate 90formed on the end of a supporting stem 91, which extends axially fromthe end wall 87 of the mixing head and is of such a length that theclosure plate 90 resiliently engages the outer surface of the diluentchamber end wall 85 when the inturned flange 88 of the mixing head hasbeen pressed over the tapered flange 89, into the position shown in FIG.7. The closure plate 98 preferably is formed with a plurality ofrelatively shallow sealing protrusions or pimples 92 which are spacedapart and positioned on the outer surface of the closure plate 90 in thesame arrangement as the dis ensing passageways or orifices 85 in the endwall 8d of the diluent chamber.

In packaging this embodiment of the storing and mixing device, thedesired quantity of medicament is placed within the medicament chamberformed by the Walls of the mixing head, and the diluent chamber then ispressed into position with the end wall 84 thereof in engagement withthe flexible closure plate 90 to a position wherein the tapered flange89 thereof passes completely through the inwardly extending flange 88 ofthe mixing head and forms a retaining latch engagement therewith, asshown in FIG. 7. In order to assure a complete sealing of the medicamentchamber from the diluent chamber, the diluent chamber is turned untilthe protrusions 92 on the closure plate 98 extend into the orifices. 85,so as effectively to seal these orifices. The flexing of the closureplate 9t? by the pressure of the diluent chamber on this plate tends tohold the protrusions 92 in secure sealing engagement with the sides ofthe orifices or passageways 85, so as to prevent leakage of materialbetween the diluent chamber and the medicament chamber.

In this construction, it is desirable to have an indication to anoperator of the relative position of the mixing head and the diluentchamber, so that an operator will know when the mixing orifices aresealed by the closure plate 96} and when these orifices are open andprovide passageways between the medicament and diluent chambers. Thiscan readily be provided by forming a guide slot 93 in the side wall 86of the mixing head and positioning the mixing head over the diluentchamber so that this guide slot 93 extends over a lug M formed on theouter surface of the end wall of the diluent chamber. This arrange 1 entis more clearly shown in the sectional view illustrated in FIG. 8, whichshows the diluent chamber lug EM;- extending into the guide slot 93 ofthe mixing head, at one end of the slot. In this position, the lug 94-acts as a stop on the diluent chamber wall which limits the relativeturning of the mixing head and the diluent chamber to a position inwhich the protrusions 92 on the closure plate are in sealing positionover the orifices or passageways 85. In order further to assure againstleakage during storage of the device, a light heat seal preferablyadditionally is formed around the outer edge of the flange 88 on themixing head. Such a seal can readily be formed when both the mixing headand the diluent chamber are formed of plastic by pressing the surface ofthe diluent chamber wall 83 with a heated instrument, so

1 that a light adhesive bond 5 is formed between the outer surface ofthe flange 88 and the adjacent surface of the side wall of the diluentchamber. This provides a further effective seal and assures againstleakage or contamination of medicament in the medicament chamber duringstorage of the device.

When it is desired to use the medicament for medicinal purposes, amixing of the diluent and the medicament can readily be performed bysimply turning or twisting the mixing head relative to the diluentchamber in a direction permitted by the slot 93 and suitably shaking thedevice. Such a relative turning of the mixing head and the diluentchamber again is limited by engagement of the lug 94 with the end of theslot 93, opposite to that shown in FIG. 8. In this position the closureplate 98 is turned relative to the end wall 84 of the diluent chambersuch that the protrusions 92 are raised over the outer surface of theend wall 84 out of sealing position with the orifices or passageways 85.This raised position of the protrusions flexes the closure plate awayfrom the adjacent surface of the end wall 84 and provides for an openingof the mixing orifices or passageways 85 to permit the passage ofdiluent from the diluent chamber into the medicament chamber by simplysqueezing the pliable diluent chamber walls 83, so that the diluent andthe medicament may be thoroughly mixed. The mixture then can return intothe diluent chamber by way of the open passageways 85 to be dispensedfrom the device through the dispensing head on the opposite end of thediluent chamber.

If desired, the diluent chamber may have an arrow placed on the outerwall thereof adjacent to the lug 94 to :indicate the direction in whichthe diluent chamber should be turned relative to the mixing head inorder to open the mixing passageways 85. Such a turning of the diluentchamber relative to the mixing head will break the light heat seal bond95, but this will not affect the leak-proof seal formed between theflanges 88 and 89 as the turning sealing engagement with each other dueto the added pressure exerted therebetween by the flexing of the closureplate as the protrusions 92 are raised when they are disengaged fromtheir positions over the passageways 85 and slide over the outeradjacent surface of the diluent chamber end wall 84. This simplifiedconstruction includes all of the advantages of the embodiments of thepresent invention shown in FIGS. 1 through 6 and rninimizes the numberof relatively movable sealing and contacting surfaces, therebyminimizing the possible sources of leakage and also eliminates the needfor screw threaded securing means. The entire device preferably isformed of pliable plastic material which provides the desiredflexibility and resiliency to the various co-acting parts of the device.

FIG. 9 illustrates another embodiment incorporating this invention for adevice for separately storing and for mixing and dispensing a medicamentand a diluent. This device is provided with a diluent chamber having asubstantially cylindrical pliable side wall 96 provided at one endthereof with a suitable dispensing head of the drip or syringe type andformed at the other end thereof with a mixing end portion in the form ofa substantially cylindrical section 97 closed at the outer end thereofby an end wall 9%. Mixing orifices are formed in the sides of thecylindrical section 97 adjacent to the end wall 98 in the form of slotson both sides of which a pair of sealing Q-rings ltlit and 11% areformed. A mixing head is secured over the mixing end of the diluentchamber and is formed with a side wall Hi2 and an end wall me, whichprovide a medicament chamber over the end of the end wall 8 of thediluent chamber.

This mixing head is adapted to be secured to the diluent chamber by aninturned threaded flange 103, which threadedly engages a threadedsection we of the outer surface of the cylindrical section 97 of thediluent chamber. The mixing head side wall M92 also is formed with aninwardly extending shoulder 1535, which is adapted to cooperate with thetwo pairs of sealing O-rings 100' and M1 to provide a snug sliding sealtherewith.

in order to provide for effectively sealing the device and for the mostefficient utilization of the space within the operable parts the sealingshoulder is spaced axially from the inturned threaded flange 103 by agroove 1% having an axial extent C which is greater than the dis- .tanceD of the inner edges of the slots 99 from the outer surrace of the endwall 88. This allows for the easy screwing of the inturned flange 163over the threaded section 184 to a position wherein the slots 99 areexposed into the medicament chamber. In order to assure proper spacingof the mixing head and the mixing end portion of the diluent chamber, aremovable split snap-on safety ring 107 is arranged around the threadedsection 104 between the end of the mixing bead flange 103 and anadjacent shoulder 1438 on the end of the diluent chamber. This safetyring is tormed of a width C substantially equal to the axial extent C ofthe slot 1%, so that, when the mixing head is drawn up on the threadedsection lit-i of the diluent chamher, the sealing O-rings 1% and ltllwill effectively engage the inner surface of the flange 105 and seal themixing slots 109 against all possible leakage of diluent from thediluent chamber into the medicament chamber or out of the device. Thisarrangement also assures that the mixing slots 99 will be fully exposedto permit passage of diluent into the medicament chamber for mixing ofthe diluent and medicament by simply removing the split safety ring 107and screwing the diluent chamber further into the mixing head until theend of the threaded flange 1G3 engages the shoulderlfid of the diluentchamber.

In order to facilitate the relative movement of the diluent chamber andthe mixing head to provide for a mixture of the diluent and themedicament, the mixing head also preferably is provided with a ventingarrangement similar to that shown in FIGS. 2 and 5. In this arrangement,a vent plug It)? may be conveniently formed with a stem 110, whichthreadedly engages a passageway 1.11 in the end wall 1&3 of the mixinghead. The vent plug is formed with an axially extending relatively smallvent passageway 112 which is open at the end of the stem 1m andterminates inwardly of the plug in a relatively small transverselyextending vent passageway 113, which is spaced slightly from theadjacent under surface of the vent plug 109. The end wall 163 of themixing head preferably is formed with a sealing O-ring 114, which isadapted to be engaged by the adjacent under surface of the vent plug 199when the plug is screwed tightly into the end wall 103, thus providing aleak-proof seal of the vent passageways. in most instances it will befound desirable to vent the medicament chamber before screwing themixing head over the threaded section 1% for mixing the diluent and themedicament. This can easily be done by simply backing off the vent pluga turn or two, so as to expose the ends of the transverse passageway 113in order to facilitate screwing the mixing head down over the threadedsection lit i of the diluent chamber cylindrical section 97. As in theother constructions provided with a venting arrangement, the diluentchamber should be substantially completely filled with diluent and themixing of the diluent with the medicament should be done with the mixinghead held above the diluent chamber in order to avoid spilling orleaking of diluent out of the device through the ent passageways, thediluent bein squeezed out of the diluent chamber into the medicamentchamber in the mixing head by simply squeezing the sides of the pliableside wall ,6 of the diiuent chamber. This construction provides asubstantially more sturdy device than some of the previously describedarrangements, and may be preferable for certain materials and certainuses of such a device.

A still further embodiment of the present invention is illustrated inP16. 10, wherein a device is shown for separately storing and for mixingand dispensing medicament and a diluent, which includes a diluentchamber having a pliable side wall 115 formed of any suitable material,such as plastic, and adapted to be closed at one end thereof by asuitable dispensing head of the drip or syringe-connector type, andclosed at the opposite end thereof by a closure end wall or diaphragm116 extending across a mixing end portion 117. In this construction, amixing head is secured over the mixing end portion of the diluentchamber. This mixing head includes a substantially cylindrical side wall118, which is closed at one end thereof by an end wall 119 and isprovided with a threaded inwardly extending shoulder 124] on the endthereof opposite the wall 119 adapted threadedly to engage a threadedportion 121 of a shoulder on the outer surface of the end portion 117.In order to provide for the ready threaded engagement between theshoulder 126 and the threaded portion 121, the outer surface 122 of theportion 117 is formed on a smaller diameter than that of the threadedshoulder 120. The mixing head forms a cup-shaped closure, which extendsover the mixing end portion H7 and together therewith forms a medicamentchamber 123.

In order to provide for passage of diluent from the diluent chamber 124into the medicament chamber 123, a piercing or cutting blade 125, havinga fluted end 125, extends from the end wall 119 of the mixing headtowards the open end thereof. The sharp piercing end of this cuttingblade is adapted to rest against the adjacent surface of the end wall ordiaphragm N6 of the mixing end portion 117 of the diluent chamber whenthe threaded shoulder 12d of the mixing head is screwed onto thethreaded portion 12% such that a pair of sealing Ov-rings 125 adjacentthe outer end of the mixing end portion 117 snugly and sealingly engagethe inner surface 118' of a shoulder on the side wall 118 of the mixinghead. With such a construction, medicament or vaccine in a dry form maybe placed in.the medicament chamber 123 and the mixing head then can bescrewed onto the threaded portion 13 121 of the mixing end portion 117of the diluent chamber. In order to assure the proper positioning of thepiercing blade 125 against the end wall or diaphragm 116 for storage ofthe device, a removable split snap-on safety ring 127 is placed aroundthe lower end of the threaded portion 121.

In assembling this embodiment of the device, the medicament or vaccinefirst is placed in the medicament chamber 123 and the mixing head isscrewed into the position shown in FIG. 10. The diluent chamber 124 thenis filled with diluent and a dispensing head 12% is fitted snugly withinan inwardly extending sealing shoulder 129 formed on the end of thediluent chamber wall 115 away from the medicament chamber 123. In theillustrated construction, the dispensing head is shown as a syringe typedispensing head attachment, although a drip type head, such as thatshown in FIG. 1, could also be used for closing this end of the diluentchamber, if desired.

The illustrated dispensing head includes an end wall 130 which forms atight pressed fit Within the sealing shoulder 129 and is formed with asloping inner surface 131 to provide for a better drainage of liquidfrom the diluent chamber 124 through a dispensing passage 132, whichextends through the wall 130 and opens into an enlarged passage 133formed in a syringe-connecting collar 134. The passage 133 is adapted tobe sealed by a suitable end plug 135, which can be held in sealingposition in the passage 133 in any convenient manner, as by a cap 136arranged over the plug 135 and adapted to have a threaded engagementwith the outer threaded surface 134' of the collar 134. If desired, sucha cap and the plug 135 may be made as an integral unit. In order furtherto assure diluent chamber 124 past the sealing shoulder 129, thedispensing head 123 also preferably is formed of a suitable plastic andthe sealing shoulder 129 is heat sealed to the adjacent surface of thedispensing head 128, after the diluent chamber has been filled and thedispensing head pressed into position within the sealing shoulder 129.

In order to prepare the medicament and the diluent for use as a liquidmixture thereof, the spacing snap-ring 127 is removed and the mixinghead is screwed down over the threaded portion 121, so that the flutedpiercing end 125 of the blade 125 pierces the end wall or diaphragm 116to permit diluent to flow from the diluent chamber 124 through flutes inthe fluted end 125 of the piercing blade, and into the medicamentchamber 123. In order to facilitate the piercing of the end wall 116 bythe blade 125 and to facilitate screwing down of the mixing head, agroove 137 is formed along the inner surface of the mixing head wall 118which has a width E substantially equal to the width E of the spacingsafety ring 127. This groove 137 permits the mixing head to be screweddown over the threaded portion 121 without interference with the threadsof this portion.

In order further to facilitate the screwing down of the mixing head, aventing arrangement preferably is provided which includes a relativelysmall venting passage 138 which extends through the blade 125 andterminates in another relatively small venting passage 13? extendingsubstantially axially through the blade 125 and terminating in athreaded vent plug socket 141 For normal storage conditions, a vent plug141, having a threaded stern 142, threadedly engages the vent plugsocket 14-11 and is drawn up tightly against a sealing O-ring 143 on theouter surface of the mixing head end wall 119, so as to prevent theescape of material from the medicament chamber through the ventpassages. This vent plug 141 is formed with an axially extending ventpassage 144, which is open to the inner end of the stem 142 andterminates inwardly in a transversely extending vent passage 1 15. Thetransverse vent passage 145 is axially against leakage of diluent fromthe spaced a small distance from the inner surface 146 of the vent plug,so that when the vent plug 141 is drawn up tightly in the threadedsocket 14% the transverse vent passage 145 is securely sealed againstleakage by the engagement of the sealing O-ring 143 with the adjacentsurface 146 of the vent plug.

When it is desired to screw the mixing head downwardly over the threadedportion 121 in order to pierce the end wall 116 by the blade 125, thevent plug 141 should be backed off one or two turns so as to break theseal between the O-ring 143 and the adjacent surface 146 of the ventplug, thereby to permit the escape of air from within the medicamentchamber 123 through the venting passages. In order to assure againstspillage and leakage of material from the device during mixing ofdiluent with medicament, the outer edge of the mixing end portion 117preferably is formed with a sealing O-ring 14-7 and the axial length ofthe mixing end portion 111 relative to the length of the side wall 118of the mixing head preferably is made such that the axial distance Fbetween the inner surface of the mixing head end wall 119 and thesealing O-ring 147 is slightly less than the width E of the spacing ring127. Thus, when the mixing head is fully screwed down over the threadedportion 121 the sealing O-ring 147 will have a snug sealing engagementwith the inner surface of the end wall 11% and will assure againstleakage of material out of the medicament chamber 123 between theadjacent side walls of the mixing head and the mixing end portion.

With this construction, the procedure of mixing diluent with medicamentshould be performed with the mixing head held above the diluent chamber,so that liquid will not be spilled or splashed out of the vent passagesthrough the vent plug 141 as the side wall of the diluent chamber issqueezed to force the diluent from the diluent chamber 124- into themedicament chamber 123. In most instances in a vented construction ofthe present type, it will be found preferable to screw down the ventplug 141 tightly into sealing engagement with the O-ring 143 when it isdesired to dispense the mixed liquid from the device through thedispensing head 128. If desired, the vent plug 1 11 need not thus besealed, but in such a case care must be exercised to hold the vent plugend of the device uppermost to prevent squirting of material outwardlythrough the vent passages when the side 115 of the diluent chamber issqueezed during the dispensing operation. Even this precaution, however,may be found undesirable, as liquid may remain in the medicament chamber123 and may be forced outwardly through the vent passages during such adispensing operation. It will be found that this embodiment of thepresent invention is particularly useful where it is desired to providean absolutely solid wall seal between the medicament and the diluent forstorage purposes.

While particular embodiments of this invention have been illustrated anddescribed, modifications thereof will occur to those skilled in the art.It is to be understood, therefore, that all arrangements andconstructions within the spirit and scope of this invention are intendedto be covered in the appended claims forming a part of this app ication.

We claim:

1. A device for separately storing and for mixing and dispensing amedicament and a diluent including a medicament chamber, a diluentchamber, means including an integral wall of said diluent chamberforming a closure between said chambers having a passage therethroughadapted to communicate with both of said chambers, means securing saidchambers together in relatively movable relationship, means for sealingsaid passage and providing for opening of said passage and the mixing ofthe medicament and diluent and for the passage of the medicament intothe diluent chamber through said passage, said diluent chamber having adispensing aperture therein removed from said medicament chamber, meansother than said securing means for sealing relatively movable adjacentsurfaces on said two chambers to provide an externally substantiallyleakproof seal therebetween, removable closure means over saiddispensing aperture, and said diluent chamber having walls formed ofresilient deformable material for exerting pressure on the mixture ofmedicament and diluent whereby such mixture may be dispensed throughsaid dispensing aperture.

2. A device for separately storing and for mixing and dispensingmedicament and a diluent including a dry medicament chamber, a diluentchamber, means including a wall forming a closure between said chambersand having a passage therethrough extending between said chambers, meanssecuring said chambers together in relatively movable relationship andproviding for sealing and opening said passage by relative movementbetween said chambers, means other than said securing means for sealingrelatively movable adjacent surfaces on said two chambers to provide anexternally substantially leakproof seal therebetween, said diluentchamber having a dispensing aperture therein removed from saidmedicament chamber, removable closure means over said dispensingaperture, said medicament chamber having a vent aperture, means forclosing said vent aperture, and said diluent chamber having walls formedof resilient deformable material for varying the pressure thereinwhereby material may be expelled therefrom and aspirated thereinto toprovide for mixing of medicament and diluent and for dispensing themixture thereof through said dispensing aperture when open. 3. A devicefor separately storing and for mixing and dispensing a medicament and adiluent including a medicament chamber, a diluent chamber having wallsformed of resilient deformable material, means for securing saidchambers together to form a unit thereof with said chambers inrelatively movable relationship, means other than said securing meansfor sealing relatively movable adjacent surfaces on said two chambers toprovide an externally substantially leakproof seal therebetween, meansincluding an integral wall of said diluent chamber for providing apassage between said chambers by relative movement thereof whereby themedicament and the diluent may be mixed and the medicament may pass intothe diluent chamber, and said diluent chamber having a droplet formdispensing portion removed from said medicament chamber.

4. A device for separately storing and for mixing and dispensing amedicament and a diluent including a medicament chamber, a separatediluent chamber movable relative to said medicament chamber, means formounting said chambers together to form a unit thereof with saidchambers in relatively movable relationship, said mounting meansincluding complementary screw-threaded engaging portions with relativelymovable sealing means adjacent to said threaded portions, meansincluding said threaded portions for providing a passage between saidchambers by relative movement thereof whereby the medicament and thediluent may be mixed and the medicament may pass into the diluentchamber, said mounting means additionally including displacementlatching and chamber movement limiting means with sealing means againstexternal leakage, said diluent chamber having a dispensing aperturetherein removed from said medicament chamber, removable closure meansover said dispensing aperture, and said diluent chamber having wallsformed of resilient deformable material for exerting pres- .sure on themixture of medicament and diluent therein whereby such mixture may bedispensed through said dispensing aperture.

5. A device for separately storing and for mixing and Ed dispensing amedicament and a diluent including a medicament chamber, a separatediluent chamber movable relative to said medicament chamber, means formounting said chambers together to form a unit thereof with saidchambers in relatively movable relationship, said mounting meansincluding complementary screw-threaded engaging portions with relativelymovable sealing means adjacent to said threaded portions, meansincluding said threaded portions for providing a passage between saidchambers by relative movement thereof whereby the medicament and thediluent may be mixed and the medicament may pass into the diluentchamber, said mounting means additionally including displacementlatching and chamber movement limiting means with sealing means againstexternal leakage, and said diluent chamber having a dispensing portiontherein removed from said medicament chamber.

6. A device for separately storing and for mixing and dispensing amedicament and a diluent including a container forming a diluent chamberand having walls of resilient deformable material, a medicament chamberhaving walls overlaying in part said diluent chamber walls, meansincluding another wall integral with said diluent chamber forming aclosure between said chambers, a passage through one of said diluentchamber walls adapted to communicate with said medicament chamber whenopen, passage sealing means, means securing said chad bers together inrelatively movable relationship whereby said passage sealing means maybe operated to passage sealing and opening positions by relativemovement of said chambers to provide for mixing of the medicament andthe diluent and for the passage of the medicament into the diluentchamber through said passage, said diluent chamber having a dispensingmeans removed from said medicament chamber, and means other than saidsecuring means for sealing relatively movable adjacent surfaces on saidtwo chambers to provide an externally substantially leakproof sealtherebetween.

7. A device for separately storing and for mixing and dispensing amedicament and a diluent including a container forming a diluent chamberand having Walls of resilient deformable material, a medicament chamberadjacent to said diluent chamber and having walls overlaying in partsaid diluent chamber walls, means including another wall integral withsaid diluent chamber forming a closure between said chambers, a passagethrough said diluent chamber walls overlaid by said medicament chamberwall and adapted to communicate with said medicament chamber when open,passage sealing means, means securing said chambers together inrelatively movable relationship whereby said passage sealing means maybe operated to passage sealing and opening positions by relativemovement of said chambers to provide for mixing of the medicament andthe diluent and for the passage of the medicament into the diluentchamber through said passage, said diluent chamber having a dispensingmeans removed from said medicament chamber, and means other than saidsecuring means for sealing relatively movable adjacent surfaces on saidtwo chambers to provide an externally substantially leakproof sealtherebetween.

References Cited in the tile of this patent UNITED STATES PATENTS2,484,755 Smith Oct. 11, 1949 2,490,553 Smith Dec. 6, 1949 2,724,383Lockhart Nov. 22, 1955 2,787,268 Greenspan Apr. 2, 1957 2,841,145 EppsJuly 1, 1958 FOREIGN PATENTS 933,444 France Dec. 17, 1947

